Professor

  • Yong-Seok Oh Ph.D
  • Yong-Seok, Oh
    Associate Professor

introduce

  1.   Education/Training

INSTITUTION AND LOCATION

DEGREE

Completion Date

FIELD OF STUDY

Seoul National Univ., Seoul, Korea

 

POSTECH, Pohang, Korea

 

B.S.

 

M.S.

Ph.D.

1997.03

 

1999.03

2004.08

Animal Sci. and Tech. (MAJOR)

Microbiology (MINOR)

Life Science

Life Science

 

Post-Doctoral Res.

2005.12

Life Science / Biotech.

The Rockefeller University, NY, US

Post-Doctoral Associate

2007.12

Molecular Psychiatry

 

Research Associate

2014.01

Molecular Psychiatry

  2.    Positions 

INSTITUTION & LOCATION

Department

Position

Term

DGIST, Daegu, Korea

 


DGIST, Daegu, Korea

 


The Rockefeller University, NY, US

Brain-Cognitive Sciences Department

 


Laboratory Animal Resource Center (LARC)

 

Molecular and Cellular Neuroscience Lab.

Assistant Professor

Associate Professor

Acting Director

Director


Adjunct Faculty

2014.01 – 2019.02

2019.03 - Present


2015.09 – 2016.12

2017.01 – Present


2017.01 – 2019.03

  3.    Fellowship/Award program

 

Program

Host Institution

Position

Year/Term

Korea Oversea Postdoctoral Fellowship

The KSMCB Travel Grant Award

 

The NARSAD* Young Investigator Award

Korean Research Foundation, Korea

 

Korean Society for Mol. & Cell Biol., Korea

Brain & Behavior Research Foundation, US

Recipient

 

Recipient

 

Awardee

(Grant PI)

2006

 

2013

 

2013

(2014~2016)

4.    Academic Memberships 

Academic Organization

Position

Term

The Korean Society for Biochemistry and Molecular Biology, Member

The Korean Society for Molecular and Cellular Biology, Member

The Society for Neuroscience, Member.

The Korean Society for Brain and Neural Science, Member

Member

Member

Member

Member

1997 – 2004

1999 – Present

2006 – Present

2013 – Present

   

  5.    Biographical Sketch

    Dr. Oh received a B.S degree at Seoul National University (SNU, Korea) in 1997 and an MS/Ph.D. degree at POSTECH (Pohang University of Science and Technology, Korea) in 2004. His major research project during the graduate course was to characterize a regulatory protein complex for G-protein-coupled receptors (GPCR) that have wide implication in human physiology. In his thesis work, he found a PDZ domain-containing protein, NHERF2 defines the specificity and the efficacy in GPCR-mediated phospholipase C (PLC) activation, by scaffolding the receptor and the effector into a functional signaling unit. During this period, Dr. Oh had the opportunity to learn various biochemical research fields. In addition, he was trained for cell biological studies to examine the subcellular locations of the protein complexes and their physiological roles in the subcellular compartments at the level of the cell. As additional achievements, he has explored the molecular dynamics of the signaling complexes of GPCR and also elucidated their role in normal and pathophysiological conditions.  

       

       When Dr. Oh joined Dr. Paul Greengard’s lab for post-doctoral training in 2006, Dr. Greengard’s lab had identified a protein called p11, which regulates depression-like states and mediates antidepressant actions. Based on Dr. Oh’s observation that p11 exists in a heterotetrameric form with annexin A2 (AnxA2) in the brain, he searched for intracellular regulatory targets of this heterotetramer. Dr. Oh found a chromatin-remodeling factor called SMARCA3 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3). Biochemical and cell biological studies revealed that the p11/AnxA2 heterotetramer regulates localization of SMARCA3 inside the nucleus and increases DNA binding affinity of SMARCA3. Dr. Oh also identified mossy cells and basket cells in the dentate gyrus, in which p11/AnxA2 regulates SMARCA3. Furthermore, Dr. Oh performed in vivo studies using SMARCA3 knockout mice and showed that SMARCA3 is required for antidepressant-induced neurogenesis and behaviors in a p11-dependent manner. His study contributed to our understanding of the molecular and cellular mechanism underlying the therapeutic delay of the current antidepressant medication over long-term administration more than several weeks. During this postdoctoral training period, his research was based not only on biochemical, molecular & cell biological techniques, but also on genetic, genomic, behavioral techniques for which he has built up strong expertise in the end. As a result of these experiences and academic achievements, Dr. Oh was assigned to serve as an assistant professor at the DGIST.

       

       As a head of Molecular Psychiatry Laboratory, Dr. Oh initiated his own project to address several important questions related to depression and antidepressive actions: How does chronic stress exposure or chronic antidepressant treatment regulates the excitability of individual neuronal subtype in the hippocampus?; which genes are regulated in each neuronal subtype?; how do these genes alter the excitability of given cell type?; How does the interplay between multiple neuronal subtypes within the circuit, cooperate to mediate behavioral responses to stress and antidepressant? To address these questions, Dr. Oh has performed the experiments with the grant supports from NARSAD Young Investigator Grant (US) and National Research Foundation of Korea (NRF, Korea). Recently, Dr. Oh works elucidated a role of hippocampal mossy cells as a key mediator of neurogenic and behavioral responses to chronic antidepressant administration. And he is further addressing the transcriptional mechanism for antidepressant actions in the hippocampus, by comparative profiling the cell-type specific transcriptome of mossy cells and granule cells in the dentate gyrus. He has identified a subset of genes that display cell-type specific expression and further are altered by antidepressant treatment. Although yet completed, his effort has revealed a significant role of neuromodulation systems including dopamine, neuropeptides to mediate the neuroadaptive changes and also the behavioral responses to chronic antidepressant treatment. All the information from his works may provide us the novel target molecules for developing fast acting, rapid antidepressant, but with less adverse effects in comparison to classical serotonergic antidepressants.

       

       In addition, Dr. Oh started building up experience in mentoring trainees including the instruction and guidance of a postdoctoral fellow, graduate and undergraduate students at DGIST. Together with all his lab members, he has developed animal models to mimic human depressive disorder (chronic stress/antidepressant treatment models, genetic KOs, AAV-injected models) in its affective and cognitive dysfunctions. Furthermore, his team has established a battery of the state-of-the-art techniques to profile the cell-type specific transcription (TRAP: translating ribosome affinity purification), and to monitor or manipulate the neuronal activity (Inscopix endoscopic imaging/fiber photometry, optogenetics/chemogenetics). In the future, as a principal investigator in the field of academic medicine, Dr. Oh would like to explore the molecule/cell/circuit basis underlying the neuropsychiatric disorders, which may eventually contribute to the development of advanced therapeutics for the patients with mental illness.